The mission of the Filgueira Lab is to transform nanotechnology-based platforms for long-term sustained release of therapies for both local and body wide applications to improve prevention and treatment of chronic diseases. By engineering nanomaterials, the obstacles of conventional therapeutic intervention can be surpassed through sustained release, targeted drug therapy, and local delivery to a specific site of action. Local delivery improves the bioavailability of the therapeutic and reduces off-target adverse effects. Nanoparticles also offer a means to transport agents to diseased cells or tissues or act as diagnostic tools. Implantable devices with specially designed nanochannels allow for controlled and sustained release of therapeutics from a drug reservoir near a target site, minimizing adverse effects associated with systemic drug exposure.